Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC077
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-29 15:57
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 250mg 3x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 41 individuals with a value less than 0.76 were subsequently diagnosed with PD. That is, 97.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.76 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 25, 'TN': 20, 'TP': 17, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 20, 'TN': 10, 'TP': 22, 'FP': 20}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 16, 'TN': 10, 'TP': 26, 'FP': 20}

Test Battery Details

Circle

numCircles 11
timePerCircleMean 3.92
timePerCircleCoV 0.32458
timePerCircleSlope -0.0660482
meanError 3.52761
tremorFreq 6.05469
tremorRelPower 28.7755
tremorGyroAmpMean 0.0260559
tremorGyroAmpSlope -0.0038682
tremorGyroAmpCoV 0.294647
tremorCoordAmpMean 0.72401
tremorCoordAmpSlope 0.114674
tremorCoordAmpCoV 1.3178
tremorAccAmpMean 0.0463437
tremorAccAmpSlope -0.00163958
tremorAccAmpCoV 0.194842
tremorPcRelVar 0.62666
tremorPcX 0.996231
tremorPcY -0.0867403

Circle Segment 1

Duration 7.44 s, Accuracy Estimate 1.751 (lower is better)

Circle Segment 2

Duration 4.72 s, Accuracy Estimate 2.055 (lower is better)

Circle Segment 3

Duration 3.92 s, Accuracy Estimate 1.899 (lower is better)

Circle Segment 4

Duration 3.72 s, Accuracy Estimate 2.219 (lower is better)

Circle Segment 5

Duration 3.56 s, Accuracy Estimate 1.931 (lower is better)

Circle Segment 6

Duration 3.52 s, Accuracy Estimate 1.858 (lower is better)

Circle Segment 7

Duration 3.16 s, Accuracy Estimate 1.879 (lower is better)

Circle Segment 8

Duration 2.72 s, Accuracy Estimate 6.72 (lower is better)

Circle Segment 9

Duration 3.16 s, Accuracy Estimate 9.367 (lower is better)

Circle Segment 10

Duration 3.72 s, Accuracy Estimate 6.422 (lower is better)

Circle Segment 11

Duration 3.48 s, Accuracy Estimate 2.703 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 21.584
timePerSpiralCoV 0.162035
timePerSpiralSlope -0.0279444
meanError 1.92694
tremorFreq 5.85938
tremorRelPower 25.475
tremorGyroAmpMean 0.0166073
tremorGyroAmpSlope -0.00133335
tremorGyroAmpCoV 0.316483
tremorCoordAmpMean 0.0465766
tremorCoordAmpSlope 0.000598452
tremorCoordAmpCoV 0.377153
tremorAccAmpMean 0.0528009
tremorAccAmpSlope 5.58884e-05
tremorAccAmpCoV 0.143901
tremorPcRelVar 0.665627
tremorPcX 0.614072
tremorPcY 0.78925

Spiral Segment 1

Duration 30.72 s, Accuracy Estimate 1.911 (lower is better)

Spiral Segment 2

Duration 19.0 s, Accuracy Estimate 2.19 (lower is better)

Spiral Segment 3

Duration 22.04 s, Accuracy Estimate 1.744 (lower is better)

Spiral Segment 4

Duration 19.44 s, Accuracy Estimate 2.119 (lower is better)

Spiral Segment 5

Duration 22.28 s, Accuracy Estimate 1.733 (lower is better)

Spiral Segment 6

Duration 22.6 s, Accuracy Estimate 1.759 (lower is better)

Spiral Segment 7

Duration 20.2 s, Accuracy Estimate 1.871 (lower is better)

Spiral Segment 8

Duration 20.36 s, Accuracy Estimate 1.893 (lower is better)

Spiral Segment 9

Duration 18.52 s, Accuracy Estimate 2.109 (lower is better)

Spiral Segment 10

Duration 20.68 s, Accuracy Estimate 1.94 (lower is better)

Elel

eDurationMean 0.387581
eDurationStd 0.0916594
eDurationStdnorm 0.236491
eDurationMedian 0.36
eDurationQuartdelta 0.075
eDurationQuartdeltanorm 0.208333
eDurationKurt 5.96235
eDurationTrenddiff -0.08
eDurationTrendratio 0.807229
eWidthMean 4.36297
eWidthStd 1.16539
eWidthStdnorm 0.267109
eWidthMedian 4.329
eWidthQuartdelta 1.17
eWidthQuartdeltanorm 0.27027
eWidthKurt 3.87575
eWidthTrenddiff 0.468
eWidthTrendratio 1.11765
eHeightMean 8.91842
eHeightStd 2.46251
eHeightStdnorm 0.276115
eHeightMedian 8.658
eHeightQuartdelta 2.6325
eHeightQuartdeltanorm 0.304054
eHeightKurt 3.13721
eHeightTrenddiff 0.702
eHeightTrendratio 1.08451
eAspectMean 0.495187
eAspectStd 0.0639668
eAspectStdnorm 0.129177
eAspectMedian 0.5
eAspectQuartdelta 0.0632536
eAspectQuartdeltanorm 0.126507
eAspectKurt 3.41392
eAspectTrenddiff -5.55112e-16
eAspectTrendratio 1
eSlantMean 0.000979204
eSlantStd 0.189601
eSlantStdnorm 193.627
eSlantMedian 0.0353982
eSlantQuartdelta 0.215667
eSlantQuartdeltanorm 6.09258
eSlantKurt 4.544
eSlantTrenddiff -0.0571058
eRtopMean 0.814792
eRtopStd 0.0806514
eRtopStdnorm 0.0989841
eRtopMedian 0.829268
eRtopQuartdelta 0.102968
eRtopQuartdeltanorm 0.124168
eRtopKurt 4.62138
eRtopTrenddiff -0.00573888
eRbotMean 0.811502
eRbotStd 0.361632
eRbotStdnorm 0.445633
eRbotMedian 0.777778
eRbotQuartdelta 0.444211
eRbotQuartdeltanorm 0.571129
eRbotKurt 5.95272
eRbotTrenddiff 0.203565
eRrightMean 0.902258
eRrightStd 0.0512736
eRrightStdnorm 0.0568281
eRrightMedian 0.916667
eRrightQuartdelta 0.0662979
eRrightQuartdeltanorm 0.072325
eRrightKurt 3.51484
eRrightTrenddiff 0.036681
eRleftMean 0.288448
eRleftStd 0.076015
eRleftStdnorm 0.263531
eRleftMedian 0.283582
eRleftQuartdelta 0.0942345
eRleftQuartdeltanorm 0.332301
eRleftKurt 2.4265
eRleftTrenddiff -0.0309345
lDurationMean 0.544028
lDurationStd 0.133426
lDurationStdnorm 0.245257
lDurationMedian 0.4975
lDurationQuartdelta 0.0875
lDurationQuartdeltanorm 0.175879
lDurationKurt 4.38912
lDurationTrenddiff -0.0725
lDurationTrendratio 0.868778
lWidthMean 10.1335
lWidthStd 1.84576
lWidthStdnorm 0.182144
lWidthMedian 10.0035
lWidthQuartdelta 2.34
lWidthQuartdeltanorm 0.233918
lWidthKurt 2.55534
lWidthTrenddiff 1.755
lWidthTrendratio 1.1875
lHeightMean 24.7065
lHeightStd 3.24692
lHeightStdnorm 0.13142
lHeightMedian 25.3305
lHeightQuartdelta 4.9725
lHeightQuartdeltanorm 0.196305
lHeightKurt 2.58055
lHeightTrenddiff 0.5265
lHeightTrendratio 1.02118
lAspectMean 0.410606
lAspectStd 0.0557021
lAspectStdnorm 0.135658
lAspectMedian 0.409663
lAspectQuartdelta 0.0718542
lAspectQuartdeltanorm 0.175398
lAspectKurt 2.43634
lAspectTrenddiff 0.0436884
lAspectTrendratio 1.10881
lSlantMean 0.183688
lSlantStd 0.0780994
lSlantStdnorm 0.425173
lSlantMedian 0.211155
lSlantQuartdelta 0.123277
lSlantQuartdeltanorm 0.583823
lSlantKurt 2.15565
lSlantTrenddiff 0.0181343
lRtopMean 0.867921
lRtopStd 0.049893
lRtopStdnorm 0.0574856
lRtopMedian 0.873993
lRtopQuartdelta 0.0553405
lRtopQuartdeltanorm 0.0633191
lRtopKurt 3.29091
lRtopTrenddiff 0.000832501
lRbotMean 0.423954
lRbotStd 0.156143
lRbotStdnorm 0.368302
lRbotMedian 0.395876
lRbotQuartdelta 0.216638
lRbotQuartdeltanorm 0.547235
lRbotKurt 2.62569
lRbotTrenddiff 0.0780173
lRrightMean 0.920842
lRrightStd 0.0455092
lRrightStdnorm 0.0494213
lRrightMedian 0.931237
lRrightQuartdelta 0.0581417
lRrightQuartdeltanorm 0.0624349
lRrightKurt 3.52692
lRrightTrenddiff 0.0208845
lRleftMean 0.194573
lRleftStd 0.0700234
lRleftStdnorm 0.359882
lRleftMedian 0.185418
lRleftQuartdelta 0.0823463
lRleftQuartdeltanorm 0.444111
lRleftKurt 3.24196
lRleftTrenddiff 0.0154848

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.95
sumTouchScores 19
meanMovementTime 0.811842
numTouches 20
undershootPercentage 0
overshootPercentage 5

FITTS Long Modified

meanTouchScore 0.969576
sumTouchScores 18.4219
meanMovementTime 0.990278
numTouches 19
undershootPercentage 0
overshootPercentage 5.26316

ZigZag

numZigzags 5
timePerZigzagMean 31.632
timePerZigzagCoV 0.114476
timePerZigzagSlope -0.0647446
meanError 1.91137
tremorFreq 6.83594
tremorRelPower 29.2372
tremorGyroAmpMean 0.0193932
tremorGyroAmpSlope 0.0010653
tremorGyroAmpCoV 0.426629
tremorCoordAmpMean 0.0472668
tremorCoordAmpSlope -7.50984e-05
tremorCoordAmpCoV 0.666107
tremorAccAmpMean 0.0308803
tremorAccAmpSlope 0.000740067
tremorAccAmpCoV 0.352559
tremorPcRelVar 0.823961
tremorPcX 0.41322
tremorPcY -0.910631

ZigZag Segment 1

Duration 37.76 s, Accuracy Estimate 1.795 (lower is better)

ZigZag Segment 2

Duration 31.68 s, Accuracy Estimate 2.144 (lower is better)

ZigZag Segment 3

Duration 30.4 s, Accuracy Estimate 1.622 (lower is better)

ZigZag Segment 4

Duration 29.92 s, Accuracy Estimate 1.922 (lower is better)

ZigZag Segment 5

Duration 28.4 s, Accuracy Estimate 2.073 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 17.864
timePerZigzagCoV 0.185704
timePerZigzagSlope -0.0987461
zigzagHeightMean 82.4473
zigzagHeightCoV 0.0999071
zigzagHeightSlope 0.0630074
meanError 0.0649698
tremorFreq 6.93359
tremorRelPower 22.782
tremorGyroAmpMean 0.0293863
tremorGyroAmpSlope 0.000136504
tremorGyroAmpCoV 0.368859
tremorCoordAmpMean 0.0838447
tremorCoordAmpSlope 0.00370221
tremorCoordAmpCoV 0.228424
tremorAccAmpMean 0.0497646
tremorAccAmpSlope 0.000483798
tremorAccAmpCoV 0.309317
tremorPcRelVar 0.792507
tremorPcX 0.381367
tremorPcY -0.924424

ZigZag Offset Segment 1

Duration 19.64 s, Accuracy Estimate 0.057 (lower is better)

ZigZag Offset Segment 2

Duration 20.64 s, Accuracy Estimate 0.058 (lower is better)

ZigZag Offset Segment 3

Duration 20.48 s, Accuracy Estimate 0.093 (lower is better)

ZigZag Offset Segment 4

Duration 14.84 s, Accuracy Estimate 0.067 (lower is better)

ZigZag Offset Segment 5

Duration 13.72 s, Accuracy Estimate 0.05 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.72}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.76}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.9999999956088881}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9381683427346252}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5902799076172822}